Iryo is the brand of high-speed rail services in Spain of the operator Intermodality of Levante S.A. (ILSA). In December 2022, it began to provide service on the Madrid-Barcelona line with 16 daily frequencies in each direction. The rolling stock is the ETR 400, also known as V300 Zefiro, Frecciarossa 1000 or ILSA Series 109 in Spain, an Italian high-speed train of the latest generation.